PUBLICACIONES CIENTÍFICAS Y ACADÉMICAS

Permanent URI for this collectionhttp://rid.isalud.edu.ar/handle/123456789/15

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Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
(2022) Urueña, Analía; Micone, Paula; Magneres, María Cecilia; McGovern, Ian; Mould-Quevedo, Joaquín; Rocha Sarmento, Túlio Tadeu; Giglio, Norberto
Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the payer and societal perspectives. Methods: A static decision tree model compared the costs and health benefits of vaccination with QIVc vs. QIVe using a one-year time horizon. The relative vaccine effectiveness of QIVc vs. QIVe was assumed to be 8.1% for children and 11.4% for adults. An alternative high egg-adaptation scenario was also assessed. Model inputs were sourced from Argentina or the international literature. Deterministic and probabilistic sensitivity analyses were performed. Results: Compared to QIVe, QIVc would prevent 17,857 general practitioner visits, 2418 complications, 816 hospitalizations, and 12 deaths per year. From the payers’ perspective, the incremental cost-effectiveness ratio per quality-adjusted life years gained was USD12,214 in the base case and USD2311 in the high egg-adaptation scenario. QIVc was cost-saving from the societal perspective in both scenarios. Conclusions: QIVc in Argentina would be cost-effective relative to QIVe. The potential health benefits and savings would be even higher in high egg-adaptation seasons.
Cost-Effectiveness Analysis of Switching from Trivalent to Quadrivalent Seasonal Influenza Vaccine in Argentina
(2022) Urueña, Analía; Micone, Paula; Magneres, María Cecilia; Mould-Quevedo, Joaquín; Giglio, Norberto
The burden of seasonal influenza disease in Argentina is considerable. The cost-effectiveness of trivalent (TIV) versus quadrivalent influenza vaccine (QIV) in Argentina was assessed. An age-stratified, static, decision-tree model compared the costs and benefits of vaccination for an average influenza season. Main outcomes included: numbers of influenza cases; general practitioner (GP) visits; complicated ambulatory cases; hospitalizations; deaths averted; and costs per quality-adjusted life years (QALYs) gained. Epidemiological data from Argentina for 2014–2019 were used to determine the proportion of A and B strain cases, and the frequency of mismatch between vaccine and circulating B strains. To manage uncertainty, one-way and probabilistic sensitivity analyses were performed. Switching from TIV to QIV would prevent 19,128 influenza cases, 16,164 GP visits, 2440 complicated ambulatory cases, 524 hospitalizations, and 82 deaths. Incremental cost–effectiveness ratios (ICERs) per QALY were 13,590 and 11,678 USD from the payer’s and societal perspectives, respectively. The greatest health benefits and direct medical cost savings would occur in ≥ 65-year-olds. One-way sensitivity analyses demonstrated the principal drivers of ICER to be vaccine acquisition costs, environmental B strain predominance, and B strain mismatch. Introducing QIV in Argentina would be beneficial and cost-effective relative to TIV, particularly in older adults.
Ludopatía digital: una amenaza creciente a niños, niñas y adolescentes
(Asociación de Psicológas y Psicológos de Buenos Aires (APBA), 2024) La Blunda, Andrés; Cohen, José María
El juego compulsivo se vio acrecentado en los ultimos tiempos en franjas etarias cada vez más chicas. Por un lado, esta modalidad hace sentido con este espíritu de época, por el otro con el advenimiento de las nuevas tecnologías se abren otras posibilidades que tienen sus ventajas y desventajas. Sobre esta problemática –en cierta forma novedosa– que abarcan también los consumos problemáticos reflexionan Andres La Blunda, Jose María Cohen y Raúl Gomez.
La perspectiva de derechos humanos en las investigaciones sobre consumo problemático: Principales retos en la producción de información
(Asociación de Psicológas y Psicológos de Buenos Aires (APBA), 2024) Ruíz, Diego
El paradigma de los derechos humanos desempeña un papel crucial en las investigaciones sobre el consumo problemático de sustancias. Proporciona un marco teórico que enfatiza la importancia de abordar esta temática desde una perspectiva integral y respetuosa de los derechos de las personas involucradas.
Nuevo Centro de estudios sobre consumos y derechos humanos de la Universidad ISALUD. Una propuesta situada para el abordaje integral de las situaciones de consumo
(Asociación de Psicológas y Psicológos de Buenos Aires (APBA), 2024) Marolla, Valeria; Macías, Gaspar; Crasnich, Nancy; Moreno Role, Mauro; Cohen, José María
En el año 2023 la Universidad ISALUD llevó a cabo el relanzamiento del Centro de estudios sobre consumos y derechos humanos –CECODH1 - convocando a un equipo interdisciplinario, orientado a la investigación, formalización de teoría y diseño de estrategias para el abordaje de la temática de consumos desde una perspectiva integral, que responda a las problemáticas actuales y locales de nuestro país y en cada región.
El federalismo sanitario argentino: una perspectiva innovadora para integrar el sistema de salud nacional
(2023) Madies, Claudia
Con frecuencia, las publicaciones científicas que describen la organización del sistema de salud argentino, lo caracterizan como un sistema complejo, fragmentado y segmentado, atribuyendo mayoritariamente tales fallos, entre otras causas, a la organización política federal de nuestro país.Este artículo invita a reflexionar sobre tales características de la organización política fe-deral de la República Argentina, cuyo territorio ocupa en extensión el octavo lugar a nivel mundial, el cuarto en el continente americano (luego de Canadá, Estados Unidos de Amé-rica y la República Federativa de Brasil) y el segundo entre los países latinoamericanos.
Nursing care to prevent ventilator-associated pneumonias in adult patients
(2023) Delgado Mejía, María Bertalisa
Introduction: Pneumonia associated with mechanical ventilation is a serious complication in patients with artificial airway in intensive care units, increasing morbidity and mortality. It increases the use of antibiotics, oropharyngeal microbial resistance increasing the risk, driving the need for preventive strategies. Methods: a review of scientific articles published between (2018-2023) in PubMed was conducted. Key terms: nursing prevention, Pneumonia associated with mechanical ventilation in adults. Fourteen relevant studies were selected for analysis, looking for preventive measures of mechanical ventilation-associated pneumonia. Results: 14 articles analyzed in the last 5 years (2018-2023), focused on prevention of mechanical ventilation-associated pneumonia. The most effective preventive measures included head-of-bed elevation, oral hygiene with chlorhexidine, subglottic suctioning, and endotracheal tube pressure control. Implementation of these strategies decreased the incidence of ventilator-associated pneumonia and improved the recovery of patients on mechanical ventilation. Conclusion: ventilator-associated pneumonia represents a challenge in intensive care units, with high mortality. Preventive measures, such as bundles of care, can reduce infections and improve patient health. Nursing staff collaboration is essential for the successful implementation of preventive strategies in older patients to reduce the risks associated with mechanical ventilation and improve care in the intensive care unit
Comparative health governance in Latin America: the case of national policy decisions during pandemic response in five countries
(2023) Alonso, Cristina; Artaza, Oswaldo; Rojas, Karol; Sáenz, Rocío; Glanc, Mario; Vieira Machado, Cristiani; Lopez-Cevallos, Daniel; Torres, Irene
Context: Little is known about pandemic response in Latin America. The aim of this study was to compare key COVID-19 response measures taken by five Latin American countries to understand what elements of public governance are needed for more effective policy strategies, and to inform future pandemic preparedness. Methods: Using a qualitative, iterative approach guided by a governance framework, we analyzed the most salient characteristics of each country’s response (restriction, sanitary, and social protection measures). Findings: A focus on transparency and inclusion, together with attention to the primary level of care, appeared to be more prominent in countries with less Covid-19 incidence and mortality such as Argentina and Costa Rica. In contrast, Brazil, Chile, and Ecuador, with more fragmented and segmented health systems, coupled with less transparency and participatory decision making, were more severely impacted. Conclusions: Pandemic preparedness may benefit from emphasizing organizational, institutional, and informational elements of governance. Since data is essential to decision making in an evolving pandemic, the flow of information interacts with different elements of governance; therefore, more attention should be placed on the relation of the informational dimension with the organizational and institutional dimensions.
Meningococcal burden of disease in Argentina: 10 years epidemiologic review
(2023) Neyro, Silvina; Urueña, Analía; Efron, Adriana; Rancaño, Carolina; Pannunzio, Maria E.; Seoane, Maria B.; Gomez, Jorge A.; Giglio, Norberto
Invasive meningococcal disease (IMD) is an uncommon but serious and potentially fatal condition, mainly affecting infants. In 2017, Argentina introduced a vaccination program against serogroups A, C, W and Y (MenACWY) for infants aged 3, 5 and 15 months and adolescents aged 11 years. The objective of this study was to review the burden of IMD in Argentina in 2010–2019. Data were obtained from national surveillance databases, and the study estimated IMD incidence, mortality, case-fatality rates, and serogroup distributions across age groups. A total of 1,972 IMD cases were reported in the study period, with the highest incidence in infants aged < 1 year. Incidence peaked in 2013 and subsequently declined. Mortality rates were 18 times higher in infants than in other age groups, reflecting the high impact of IMD in this age group. The case-fatality rate was 8.5% on average and increased with age. The proportion of notified cases with serogroup identification increased over the period, reaching 91% in 2019. The most common serogroups over the study period were serogroup B (48%) and serogroup W (42%), with an increase in B relative to W since 2015. In infants aged < 1 year, the proportion of serogroup B increased in recent years, reaching around 70% of characterized cases in 2018–2019. These results show the dynamism of IMD and indicate the importance of vaccination at an early age and offering protection against predominant serogroups. These data are valuable to support evidence-based decision-making in healthcare.
What does data literacy means for you (as an educator)nowadays?
(2023) Raffaghelli, Juliana Elisa; Ferrarelli, Mariana; Kühn, Caroline
A pesar del avance en los marcos de alfabetización en datos, asociados a la discusión crítica del fenómeno de la datificación, las y los educadores se muestran inciertosal tener que trabajar en dichos temas. En parte ello se debe a la complejidad de las infraestructuras de datos que atraviesan la práctica educativa misma. En este contexto parece especialmente apropiado comprender los fenómenos discursivos, de construcción de la práctica profesional y por lo tanto del posicionamiento de las y los educadores alrededor de las problemáticas de la datificación en general, y del desarrollo de alfabetismos críticos en datos en particular, lo que llamamos "posicionamiento postdigital" Este trabajo propone un análisis autoetnográfico colaborativo de las experiencias profesionales de las tres autoras, en tanto que educadoras. Como mujeres de identidades migrantes complejas, con raíces en el Sur Global a la vez que portadoras de mestizajes europeos, nuestros caminos se cruzan a partir de un proyecto internacional donde elaboramos materiales y diseñamos actividades educativas. Nuestra historia se apoya en una base interseccional que permite expresar posicionalidades ricas, floridas de ejemplos y recursos que pueden ser caja de resonancia para la construcción de prácticas educativas agentivas en este campo de fuerzas de la postdigitalidad.
Opinions, Attitudes and Factors Related to SARS-CoV-2 Vaccine Uptake in Eight South American Countries
(2023) Urueña, Analía; Machado, Ricardo; Cunha, Juarez; López Colmano, Clara; Rancaño, Carolina; Kfouri, Renato; Pírez, Catalina; Bonvehí, Pablo; Calvo, Mario; Cuadros, Robinson; Muñoz, Greta|Rodríguez, Mónica; Torres, Jaime|Cahn, Florencia; Ballalai, Isabella
This article presents attitudes and practices regarding COVID-19 vaccination in the South American population. The study collected data from a self-administered survey distributed through social media platforms between February and April 2022 (N = 6555). The survey included questions related to participants’ sociodemographic background, flu vaccination practices, sources of information about COVID-19, and opinions regarding pandemic management and vaccination against SARS-CoV-2. The respondents agreed with the statement that COVID-19 vaccines were necessary (86.4%), effective (79.8%), safe (79.1%), and should be mandatory (64%). Overall, 83.4% accepted vaccination and 12.3% refused it completely. Main rejection reasons were safety (65.8%) and efficacy (54.9%) issues, and rushed development and approvals (49.1%). Vaccine uptake was associated with being ≥60 years, being a healthcare worker, previous influenza vaccine uptake, adherence to preventive measures, the death of ≥1 close people from COVID-19, and being informed through mass media or health authorities’ channels. Vaccine uptake inversely correlated with male gender, low educational level, and use of closed social networks for COVID-19 information purposes. This study provides valuable insights into COVID-19 vaccination attitudes and practices in South America that may be used to promote vaccine uptake in the region. Higher COVID-19 vaccination acceptance among people with previously acquired prevention habits reinforces the importance of routine health promotion strategies.
Management of pain reduction in mechanically ventilated care subjects
(2023) Mallqui Cáceres, Yaneth Marleny
Introduction: Pain is an unpleasant emotional experience linked to actual or potential injuries, concerns in intensive care units (ICU), affecting life and recovery of patients. It is essential to address this pain, classifying it with WHO criteria and guidelines. The approach is to explore types of pain and strategies for its management, seeking to improve quality of life during ICU hospitalization. Methods: A PubMed search was performed with "Pain Management" AND "nursing" AND "Artificial Respiration", filtering for studies between 2018 and 2023. After review, 11 irrelevant articles were discarded, selecting 8 that met criteria. Results: The outcome focuses on an independent approach to pain management in nursing, involving non-pharmacological measures and quality standards. This brings with it the responsibility to look for better alternatives to optimize nursing care in adequate pain management. Conclusion: The data from these studies expose relevant information highlighting the importance of adequate independent pain management and sedation by nurses in critically ill ICU patients. The opportunity to implement more effective and patient-centered approaches to improve the well-being and recovery of critically ill patients is emphasized.
Real-World Evidence in Cost-Effectiveness Analysis of Enhanced Influenza Vaccines in Adults ≥ 65 Years of Age: Literature Review and Expert Opinion
(2023) Postma, Maarten; Fisman, David; Giglio, Norberto; Márquez-Peláez,Sergio; Nguyen, Van Hung; Pugliese,Andrea; Ruiz-Aragón, Jesús; Urueña, Analía; Mould-Quevedo, Joaquin
Influenza vaccination can benefit most populations, including adults ≥ 65 years of age, who are at greater risk of influenza-related complications. In many countries, enhanced vaccines, such as adjuvanted, high-dose, and recombinant trivalent/quadrivalent influenza vaccines (aTIV/aQIV, HD-TIV/HD-QIV, and QIVr, respectively), are recommended in older populations to provide higher immunogenicity and increased relative vaccine efficacy/effectiveness (rVE) than standard-dose vaccines. This review explores how efficacy and effectiveness data from randomized controlled trials and real-world evidence (RWE) are used in economic evaluations. Findings from published cost-effectiveness analyses (CEA) on enhanced influenza vaccines for older adults are summarized, and the assumptions and approaches used in these CEA are assessed alongside discussion of the importance of RWE in CEA. Results from many CEA showed that adjuvanted and high-dose enhanced vaccines were cost-effective compared with standard vaccines, and that differences in rVE estimates and acquisition price may drive differences in cost-effectiveness estimates between enhanced vaccines. Overall, RWE and CEA provide clinical and economic rationale for enhanced vaccine use in people ≥ 65 years of age, an at-risk population with substantial burden of disease. Countries that consider RWE when making vaccine recommendations have preferentially recommended aTIV/aQIV, as well as HD-TIV/HD-QIV and QIVr, to protect older individuals.
Cuidados independientes que realizan los profesionales de enfermería en la prevención del delirio
(2023) Calcagno, María Rosenda Fernanda
Introduction: Delirium is a condition that affects attention, consciousness, and cognition, especially in older people. It can result from underlying diseases or medications. It has a great economic and social impact, with the need for special care, increased risk of falls, prolonged hospitalization and institutionalization. Methods: A literature search was performed in SciELO and Scopus with the keywords "delirium", "prevention" and "nursing" establishing inclusion and exclusion criteria to select 15 relevant articles on the independent care provided by nursing professionals in the prevention of delirium occurrence in the last 5 years and open access. Results: The importance of delirium prevention and management through nursing interventions and the use of specific tools is highlighted. The potential of technology for early detection and preventive intervention is highlighted. Nurses play an essential role in the early identification and management of delirium by implementing various interventions and assessment tools. The implementation of standardized measures and protocols to improve the quality of care is recommended, although the need for future studies to improve delirium care is suggested. Conclusion: The importance of nursing interventions in the prevention and management of delirium was observed, highlighting their effectiveness in reducing the incidence and severity. The usefulness of easily accessible tools and technologies for early detection is highlighted. On the other hand, the need for continuous research to improve patient care and quality of life was emphasized.
El baño en cama en pacientes adultos en cuidados críticos
(2023) Chavez, Nilda Elizabeth
Introduction: bed bathing is an essential intervention to provide well-being and comfort to critically ill patients, as well as to protect them from risks and threats. Prolonged hospitalization in critical care units can have negative consequences, and bed bathing has been presented as a complementary intervention to improve the care provided by nursing staff Methods: an integrative literature review was carried out in the Scopus and SciELO databases for the last 5 years, using descriptors such as "baths" and "critical care". A total of 60 articles were obtained, from which 22 relevant to the topic were selected. Results: bed bathing with chlorhexidine gluconate (CHG) has been shown to be effective in reducing bacterial colonization, healthcare-associated infections and the incidence of bloodstream infections in critically ill patients. Although positive results were observed with regular use of CHG bathing, more research is needed to define the optimal frequency and duration of treatment, as well as to evaluate possible adverse effects. The use of music to reduce pain in ventilated patients is identified. Conclusion: bed bathing is used more frequently in critical settings with CHG. Further research with larger samples and defined methods is needed to maximize its effectiveness and establish clear guidelines for its appropriate use.
Empathy in nursing professionals for care subjects with depression
(2023) Toconas, Lorena del Carmen
Introduction: empathy in nursing professionals and its impact on quality of care, as well as the challenges they face, are highlighted. Compassion fatigue" due to frequent use of empathy is explored. The study seeks to improve communication and empathic care, especially in patients with psychological health disturbance. The research aims to identify strategies for better care management. Methods: a literature search was conducted in PubMed with the keywords "empathy", "empathy", "nursing" and "depression", establishing inclusion and exclusion criteria to select 7 relevant articles on empathy in nursing professionals for care subjects with depression in the last 5 years and open access. Results: the studies provide valuable information on the psychological health of health professionals and the importance of empathy in their practice. The results highlight the need to implement effective interventions to improve the mental health of these professionals and their empathic capacity in patient care. Conclusions: empathy is crucial in nursing care, but the presence of negative mental states, such as depression, can affect it. The high prevalence of depression and anxiety disorders in mental health also influences empathy towards patients with eating disorders. Addressing stress, burnout, and stigma is essential to improve empathy in health professional practice and benefit patients
The clinical and economic value of enhanced influenza vaccines for the elderly in Argentina
(2024) Urueña, Analía; Micone, Paula; Mould-Quevedo, Joaquín; Saenz, Carolina; Delgado, Micaela; Montes, José Luis; Giglio, Norberto
Background: Enhanced influenza vaccines are the best option for the elderly. In 2021, Argentina introduced the MF59-adjuvanted inactivated influenza vaccine (aIIV) for individuals aged 65 years. and above, in the national immunization program. High dose inactivated influenza vaccine (HD-IIV) is also currently registered. This study evaluates the clinical and economic outcomes of these noted enhanced influenza vaccines for the elderly in Argentina. Methods: Using a static decision-tree model and adopting the payer's perspective during an average influenza season, the analysis incorporated influenza epidemiological data from pre-pandemic Argentinian seasons (2014–2019), strain distribution, vaccination uptake, influenza-related costs and Quality-Adjusted Life-Years (QALYs) gained. Results include two relative vaccine effectiveness (rVE) scenarios from two published meta-analyses, due to reported rVE variability, although without statistical significance expected between enhanced vaccines. Vaccination acquisition costs were obtained from aIIV manufacturer, while HD-IIV costs were estimated using local (Argentinian private sector) and international public sector data (Europe). This assessment considered one GDP per-capita (US$13,696) as a cost-effectiveness threshold and included multiple sensitivity analysis. Results: With an expected lower vaccine cost and non-significant higher rVE for aIIV vs HD-IIV (3.2 %), aIIV generated 41.4 QALYs gained and US$8.7 M savings to the Argentinean public health system. In this scenario aIIV resulted as a dominant strategy over HD-IIV. On a second scenario, where HD-IIV has a non-significant higher rVE compared to aIIV (15.9 % and 13.9 % for HD-IIV and aIIV, respectively, both vs standard-dose IIV), HD-IIV would only result cost-effective compared to aIIV if its public price is up to 25 % the incremental cost in relation to the standard-dose IIV acquisition price. Conclusions: In Argentina, the use of enhanced influenza vaccines in the elderly can increase vaccine effectiveness, reduce mortality and disease-related costs. Based on comparable effectiveness, the economic advantage of aIIV over HD-IIV confirms the current vaccination strategy employing aIIV in Argentina.
Calidad de vida profesional del personal de enfermería de una institución sanitaria de Buenos Aires
(2024) Báez-Sánchez, Carmen Juliana; Caballero-Gómez, Elvia Evangelista; Díaz, Brenda; Cabral, Marcela Noemí; Canova-Barrios, Carlos
Introducción: La Calidad de Vida Profesional es la percepción del trabajador de la capacidad para responder a las demandas de trabajo, y se ha vinculado con la seguridad del paciente haciéndolo un área de interés en materia de salud pública. Objetivo: Describir la Calidad de Vida Profesional del personal de enfermería del servicio de internación general de una institución sanitaria de la Ciudad de Buenos Aires, Argentina, en el periodo comprendido entre marzo y abril de 2023. Metodología: Estudio descriptivo, cuantitativo y transversal. Se encuestó a 35 profesionales de enfermería y se implementó el cuestionario CVP-35 en su versión en español. Resultados: Los encuestados fueron mayormente mujeres (82,86%), con edades entre los 31 y 40 años (60,00%) y de estado civil solteros (51,43%). Se encontró que el reactivo mayor puntuado fue el contar con la “Capacitación necesaria para hacer mi trabajo” con una media de 9,06 (DE = 1,98) y el menor puntuado fue el contar con el “Apoyo de los compañeros” con una media de 0,40 (DE = 0,77). Las dimensiones Carga de trabajo y Apoyo directivo fueron las mejor y peor percibidas. La Calidad de Vida Profesional obtuvo una media de 5,89 de 10. Conclusión: La Calidad de Vida Profesional fue categorizada como regular y estuvo relacionada positivamente con el turno nocturno de trabajo. Se requiere de implementar intervenciones para mejorar este aspecto en el trabajo en aras de garantizar el mejor desempeño del personal.
Human Health Impact of Municipal Solid Waste Mismanagement: A Review
(2024) De Titto, Ernesto; Savino, Atilio
Management of municipal solid waste (MSW) is frequently not properly performed. Whenever this happens, those working in the different stages of the process, as well as residents close to the dumps, face health risks. Here, we revised the documented evidence of emissions liberated during MSW management and associated health problems to investigate if systematic and reproducible relationships can be established. Besides substances released during collection and transportation, various toxic substances, predominantly in small amounts, can be released in the leachate and the biogases liberated in the disposal of MSW. Activities in the dump produce fine and coarse particles that are dispersed through the air and can enter the respiratory system, causing a series of adverse health effects, as shown by an increase in the demand for health services and the presence of respiratory symptoms and exacerbations of chronic processes. On the contrary, all the studies on the risk of developing some form of cancer by populations living in the vicinity of a waste dump have not been able to conclusively identify a causal or even circumstantial relationship that such a risk exists. Besides, no systematic association between residence near a landfill and any adverse outcome of childbirth has been found. However, the assessment of potential health effects is uncertain because of their diversity, the varied means of exposure, the uncertainty associated with exposures to low amounts of toxins when they occur over long periods, the potential synergies of various pollutants, the difficulty in establishing direct relationships between the toxicants emitted and health problems, the necessary arbitrariness in the delimitation of the dispersion area of the toxics and the practical impossibility of identifying other sources of exposure that could have some share of responsibility in the emerging health, as well as the lack of control of confounding factors like social deprivation, the lack of data on migrations to or from the most critical areas that affect exposure times or considerations about latency periods in pathologies such as cancer that does not usually manifest until years after exposure.
The economic rationale for cell-based influenza vaccines in children and adults: A review of cost-effectiveness analyses
(2024) Fisman,David; Giglio, Norberto; Levin, Myron J.; Nguyen, Van Hung; Pelton, Stephen I.; Postma, Maarten; Ruiz-Aragón, Jesús; Urueña, Analía; Mould-Quevedo, Joaquin F.
Seasonal influenza significantly affects both health and economic costs in children and adults. This narrative review summarizes published cost-effectiveness analyses (CEAs) of cell-based influenza vaccines in children and adults <65 years of age, critically assesses the assumptions and approaches used in these analyses, and considers the role of cell-based influenza vaccines for children and adults. CEAs from multiple countries demonstrated the cost-effectiveness of cell-based quadrivalent influenza vaccines (QIVc) compared with egg-based trivalent/quadrivalent influenza vaccines (TIVe/QIVe). CEA findings were consistent across models relying on different relative vaccine effectiveness (rVE) estimate inputs, with the rVE of QIVc versus QIVe ranging from 8.1% to 36.2% in favor of QIVc. Across multiple scenarios and types of analyses, QIVc was consistently cost-effective compared with QIVe, including in children and adults across different regions of the world.

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